Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. View in: PubMed Mentions:. Molecular basis of rheological modulation of endothelial functions: importance of stress direction. Molecular basis of mechanical modulation of endothelial cell migration.
Front Biosci. Annu Rev Biomed Eng. This graph shows the total number of publications by year. To see the data as text, click here. To return to the graph, click here. Or the time he officiated the wedding of a former student and flew to Taipei to do so. He and his wife, KC, hosted countless gatherings for students, faculty, and the department, where Chien served as grillmaster himself.
Chan, president of the International Union of Physiological Sciences. The Institute spurred advances like using fluorescent imaging to more accurately remove cancerous cells; using tissue engineering to repair spinal cord damage; and creating wearable technology to monitor blood pressure. Bridging engineering and medicine might seem commonsense now, but at the time it was a revolutionary idea. He was also the founding director of the UC system-wide Bioengineering Institute of California , where he contributed to collaborations in research among the 10 UC campuses, many of which he also helped launch.
In a story heard time and again, Shu was an advisor and mentor to Scott Simon, the current chair of the Bioengineering Institute of California—his fingerprints are everywhere. Not only did Chien transform the UC San Diego campus and UC system, but he also impacted the San Diego region as a whole, which has become a biotech and life science industry hub. The Institute facilitates the integration of engineering principles and novel technologies with biomedical and translational research.
As the silos between engineering and medicine continue to dissolve, there is a growing need on campus for facilities where engineers, physicians and medical researchers can work in the same physical research ecosystems. The named Chien-Farrell Institute for Engineering in Medicine Collaboratory will serve as a hub for research at the interface of engineering and medicine. This collaborative research facility is one of 13 such "collaboratories" within the Jacobs School's newest building, Franklin Antonio Hall.
The Chien-Farrell Collaboratory in particular and Franklin Antonio Hall more generally will focus not only on collaborations among researchers from disparate fields, but among academic teams and industry partners as well. They support each other in a loop where the best ideas are fed into the marketplace to generate revenue, where a portion of the profit flows back to academia in research support coupled with potential equity. This new Collaboratory and Franklin Antonio Hall accelerate that loop, delivering good ideas which solve problems into the marketplace.
Everybody benefits: it can help the campus, the students, society as a whole. I myself am a beneficiary of their product with sleep apnea, so I personally am grateful for that. I have a lot of respect for him. The institute also fosters student training, industry cooperation and entrepreneurism. Chien is widely known as an exceptional researcher, instructor, mentor, and citizen of the university and his professional community.
His research integrates biomedical sciences and engineering across the biological hierarchy, from genes and molecules to cells and tissues to organs and systems.
Some of his more recent research has focused on the effects of mechanical forces — pressure and flow — on cellular functions such as gene expression. When genes change their expression, the proteins will change, and proteins are the major determinants of cell functions such as growth, migration and programmed cell death.
His research has shown how the mechanical forces generated by circulating blood affect the functions of endothelial cells in health and disease. More specifically, this research uncovered the mechanical and molecular mechanism of the preferential distribution of atherosclerosis in regions of complex flow such as arterial branch points by establishing the differential signal processing and gene expression of endothelial cells in these regions as compared to regions resistant to atherogenesis, which is the process by which plaque forms in the arteries.
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